IVIS® Lumina XRMS System

Industry leading Fluorescence, Bioluminescence and X-Ray Imaging – All-In-One benchtop instrument

The IVIS® Lumina XRMS Series III from PerkinElmer integrates the best-in-class technology on the market for leading In-vivo bioluminescence and fluorescence imaging with low dose 2D X-ray capability. With the Lumina XRMS, get an anatomical context to optical signal in mice and rats and other large species. The Lumina XRMS includes state of the art spectral unmixing for sensitive multispectral imaging to monitor multiple biological events in the same animal.

The system is equipped with up to 26 filters tunable to image fluorescent sources that emit from green to near-infrared. All Lumina Series III systems come with a novel illumination technology that effectively increases fluorescent transmission deep into the near infrared range with full transmission through 900 nm. Moreover, the Lumina III series instruments incorporate PerkinElmer’s patented Compute Pure Spectrum (CPS) algorithm for spectral library generation software tools to ensure accurate autofluorescence removal, unmixing and fluorophore quantitation. Standard on all IVIS instruments, absolute calibration affords consistent and reproducible results independent of magnification, filter selection from one instrument to any another IVIS instrument within an organization or around the world.

An adjustable field of view from 5 – 12.5 cm and an optional 24 cm lens allows imaging of up to 5 mice or 2 medium size rats or zoom lens capability increasing the resolution to 35 μm at a field of view of 2.5 cm. The Lumina Series III can also accommodate petridishes or micro-titer plates for in vitro imaging. The system includes premium animal handling features such as a heated stage, gas anesthesia connections and ECG monitoring.

Features and Benefits:
  • Multispecies optical and X-ray imaging
  • Image mice, rats and other large animals
  • High resolution, low dose digital X-Ray
  • Exquisite sensitivity in bioluminescence
  • Compute Pure Spectrum (CPS) spectral unmixing for ultimate fluorescence sensitivity
  • Full fluorescence tunability through the NIR Spectrum

The Lumina XRMS Series III offers complete and rich calibrated datasets for longitudinal studies with supporting analysis software.

Imaging System Components:

  • Camera Sensor
  • CCD Size
  • CCD Operating Temperature
  • Imaging Pixels
  • Quantum Efficiency
  • Pixel Size
  • Minimum Detectable Radiance
  • Optical Field of View (FOV) cm
  • X-Ray Field of View (FOV) cm
  • Lens
  • Minimum Image Pixel Resolution
  • Minimum Read Noise (e-)
  • Dark Current (Typical)
  • Illumination Source Extended
  • Excitation Fluorescence Filters
  • Emission Fluorescence Filters

  • Radiation Leakage
  • Automated Aluminum Filter
  • Plate Voltage Range
  • Tube Current Range
  • Anode Material
  • Typical X-Ray Image Acquisition Time
  • Average Mouse Dosage
  • X-Ray Tube Window
  • Animal Height (cm)
  • Scintillator


Back-thinned, back-illuminated, cooled Grade 1 CCD, frame transfer
1.3 x 1.3 cm
-90 ˚C

1024 x 1024
>85% at 500-700 nm, >30% at 400-900 nm
13 microns
100 photons/s/sr/cm2

5 x 5, 7.5 x 7.5, 10 x 10, 12.5 x 12.5 (Optional zoom 2.4 x 2.4)

5 x 5, 7.5 x 7.5, 10 x 10 (Optional zoom 2.4 x 2.4)

f/.95 – f/16, 50 mm

50 microns

Better than 5
<3 x 10-4 e-/pixel/s
NIR Range 150W Tungsten EKE


Radiation Shielded Cabinet Exceeds standards set by the U.S. FDA Center for Devices and Radiological Health (21 CFR 1020.40)
<0.1 mR/hr
0.4 mm

10-40 kV
1-100 uA
10 s

1-3 mGy
0.127 mm beryllium
0-5.3 (average mouse is 2 cm, average rat is 4.5 cm)
Automated Csl plate placement during X-Ray acquisition

Hardware Specifications

  • Imaging System Space Requirement
  • Imaging Chamber Interior Dimension
  • Power Requirements
  • Stage Temperature
  • Computer (Minimum Specifications)

48 x 71 x 104 cm (W x D x H)

43 x 38 x 43 cm (W x D x H)

6A at 120V
20 – 40 °C
Windows® 7, 4 GB RAM, nVidia quadro 600, 250 GB and 1 TB HD, 24” widescreen LED Monitor
  • Oncology
  • Stem Cell Research
  • Implant biology
  • Infection Biology
  • Neurodegenerative Disorders
  • Parasitology
  • Virology
  • Cardiovascular studies
  • Pharmacokinetics/Pharmacodynamics studies
  • Crispr/Cas9 applications
  • Inflammation biology
  • Immunology research
  • Plant Biology
  • many more
  • Fluorescent agents, Dyes, Labeling Kits, and Nanoparticles
  • Bioluminescent oncology cell lines and bacterial created using luciferase (luc2) vector for utlra brite sensitivity
  • Bioluminescent substrates including D-Luciferin K+ salt and RediJect Luciferin in ready-to-use injectable format
  • Radioimaging reagents
  • Living Image® Software

Pre-Clinical In Vivo Imaging Solutions from PerkinElmer
In Vitro Bioluminescence Imaging on the IVIS Platform
In Vivo Bioluminescence Imaging on the IVIS Platform
In Vitro Fluorescence Imaging on the IVIS Platform