Cell Metric® CLD System

High throughput High Resolution Imaging tool to accelerate upstream cell line development

The Cell Metric® CLD is a high resolution high-throughput bench-top imaging system specifically designed to offer an alternative approach for ensuring cell line monoclonality and to speed up Cell Line Development (CLD). The Cell Metric® CLD system apart from its unique cell imaging and image analysis capabilities includes an integrated, temperature-controlled plate stacker. A batch of up to 10 lidded plates can be loaded manually into the stacker and the plates are automatically transferred for imaging one at a time with barcode reading. It is ideal for groups typically having throughput requirements from tens to hundreds of plates.

The Cell Metric® CLD uses non-invasive brightfield imaging for analysis of settled suspension or adherent cells. . This semi-automated image documentation can be used to prove and document mono-clonality in a regulatory compliant manner by providing a permanent record of evidence with photo documentation of cell growth and development from day 1.

Cell Metric imparts following advantages-
  • High Brightfeild image resolution enables to very well segregatedpair of cells
  • Automatic focusing ensures clear images
  • High precision XYZ positioning system
  • Uniform imaging upto the well edge
  • High throughput in imaging a batch of 10plates at a time
  • Temperature control
  • A complete audit trail report with photo documentation of cell growth and cell development from day 1

The Cell Metric® CLD can now be purchased with fluorescence detection features that enable the user to validate a new a seeding method or quality check their existing method.

Instrument Specifications

  • Image acquisition Illumination:
  • Resolution:
  • Image format:
  • Acquisition speed:
  • Cell culture containers

  • Integrated plate loader
  • Adjustable temperature control

2 µm per pixel
images stored in TIFF format
for a 96-well microplate, from <3 minutes for full scan
Most cell culture vessels that fit in an SBS microplate format footprint
(128 x 86 mm) can be imaged, including 6, 12, 24, 48, 96, 384 and 1536-well plates.
High-quality plates produce the best-quality images.
Holds 10 lidded SBS-format microtitre plates
(supports 37°C) Built-in barcode reader

Hardware Specifications

  • Dimensions (H x W x D)

  • Weight
  • Computer

650 mm x 465 mm x 500 mm/25.6” x 18.3" x 19.7"
(Instrument only, excludes PC and monitor)
50 kg, 110 lbs
Dell Precision™ workstation
Intel® Xeon® processor
500 hard disk
Microsoft Windows 7, 64-bit
24" flat screen monitor
  • Single cell cloning
  • Colony growth monitoring
  • Stable cell line generation, development and maintenance
  • Colony counting
  • Tissue engineering and stem cells
  • Cell Metrics

Cell Metric CLD - cell documentation system for regulatory
Interview with Dr Audrey Jia - Episode 1 (October 2015)
Dr Audrey Jia interview - Episode 2 (January 2016)